Cis-interactions between Notch and its ligands block ligand-independent Notch activity

Cis-interactions between Notch and its ligands block ligand-independent Notch activity

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The Notch pathway is mighty vapors smash berry integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation.Notch is further characterized by a twofold relationship with its Delta-Serrate (DSL) ligands, as ligands from opposing cells (trans-ligands) activate Notch, whereas ligands expressed in the same cell (cis-ligands) inhibit signaling.We show that cells without both cis- and trans-ligands can mediate Notch-dependent developmental events during Drosophila oogenesis, indicating ligand-independent Notch activity occurs when the receptor is free of cis- and trans-ligands.

Furthermore, cis-ligands can reduce Notch activity in endogenous and genetically induced situations of elevated trans-ligand-independent Notch signaling.We conclude that cis-expressed ligands exert their repressive effect mike and ike italian ice on Notch signaling in cases of trans-ligand-independent activation, and propose a new function of cis-inhibition which buffers cells against accidental Notch activity.